HealthDay - Research Shows Why Statins Don't Work for Everyone
A genetic quirk in the production of one protein helps explain why some people don’t get the full cholesterol-lowering benefit of statin drugs, researchers report.
Statins include blockbuster medications such as Crestor, Lipitor, Pravachol and Zocor.
The protein, abbreviated as HMGCR, plays a critical role in production of LDL cholesterol, the “bad” kind that clogs arteries, explained lead researcher Dr. Ronald Krauss, director of atherosclerosis research at the Children’s Hospital Oakland Research Center in Oakland, Calif.
Some people use the HMGCR enzyme to produce LDL in an alternative way, however, and this difference is “strongly related to the LDL-lowering effect of statins,” Krauss said.
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At the heart of the process are protein fragments called exons that are spliced together to produce an active protein, he explained. Statins block LDL cholesterol production by binding to a particular exon when the protein is assembled. But depending on how …
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